This course teaches students the ways in which business strategy and strategic decisions are affected by the recent explosion of digital technologies. Key considerations include the market and organizational context, process design, and managerial practices that determine value from data, digital infrastructures, and AI. It provides classic frameworks augmented by frontier research to make sense of digital transformation from the perspective of a general manager. Leaning on case study analysis and in-class discussion, this course will surface both practical and ethical pitfalls that can emerge in an increasingly digital world and equip students to operate effectively in professional contexts affected by these fast-moving trends.